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Protein Science (2001), 10:1264-1267.
Copyright © 2001 The Protein Society

FOR THE RECORD

Disulfide structure of alfimeprase: A recombinant analog of fibrolase

Geoff Jones, Michael Ronk, Faith Mori and Zhongqi Zhang

Analytical Research & Development Department, Amgen Inc., Thousand Oaks, California 91320, USA

Reprint requests to: Dr. Zhongqi Zhang, Amgen Inc., M/S 25–2-A, One Amgen Center Drive, Thousand Oaks, CA 91320, USA; e-mail: zzhang{at}amgen.com; fax: 805-447-8690.

The disulfide structure of alfimeprase, a recombinant analog of fibrolase, was experimentally determined by a combination of peptide mapping, Edman degradation, and mass spectrometry. The three disulfide bonds were determined to be Cys-116/196, Cys-156 /180, and Cys-158/163 with the residue number system of alfimeprase.

Keywords: Fibrolase; alfimeprase; disulfide bond; Edman degradation; mass spectrometry


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Copyright © 2001 by The Protein Society.